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PROFHILO®

PROFHILO® is an IBSA patented technology based on stabilized hyaluronic acid hybrid complexes with high and low molecular weight. This technology allows IBSA to deliver a unique concentration of hyaluronic acid: 64 mg in a pre-filled 2 ml syringe with a 29G TW needle.

2015 PROFHILO® awarded ,,EuroMedicom” and ,,Wosiam” as ,,Best Skin Enhancement Device”.

PROFHILO® CHARACTERISTICS
1
HIGH HA CONCENTRATION (64mg/2ml)
2
ULTRA-PURE PRODUCT
3
WITHOUT CROSS CONNECTION MATERIALS
4
NEW MOLECULAR STRUCTURE
5
5 BIO AESTHETIC POINTS
6
ABILITY TO FLOW UNIFORMLY THROUGH ENTIRE ANATOMIC UNITS

In vitro studies have shown that PROFHILO® improves the extracellular environment:

  • Maintaining suitable conditions for the viability of fibroblasts, keratinocytes and adipocytes.
  • Leading to a remodeling of the extracellular matrix in terms of elasticity
    and support.

 

In vitro immunofluorescence images of keratinocytes and fibroblasts compared to elastin expression

CONTROL
PROFHILO® CONTROL 0.1%
1. HIGH MOLEKULAC WEIGHT HA 0,1%
2. LOW MOLEKULAC WEIGHT HA 0,1%

PROFHILO® MECHANISM
Hybrid complexes create a triple effect
1
SUPPORT FRAME (INCREASED SKIN TURGOR) RELATED TO HIGH MOLECULAR WEIGHT HA (H-HA) LIFT.
2
MOISTURIZING EFFECT, RELATED TO LOW MOLECULAR WEIGHT HA (L-HA) HYDRO.
3
STIMULATING EFFECT, RELATED TO LOW MOLECULAR WEIGHT HA (L-HA) HYDRO.
PROFHILO® intervenes:
1
IN THE PHYSIOLOGICAL PROCESS OF AGING TISSUE, IN PRESENCE OF ALTERATIONS IN ELASTIC FIBERS AND COLLAGEN.
2
IN THE DERMAL TISSUE REPAIR PROCESS, IN CASES OF ACNE OR SCARS.
3
IN CASE OF LOSS OR COMPROMISED ADIPOSE TISSUE.

Notable for its ability to flow uniformly through entire anatomic units after injection and therefore homogeneously expanding fat compartments in challenging areas where even low viscosity fillers can produce contour irregularities.


 

Profhilo® technology helps to maintain the effect of hydrolift® action by integrating it into endogenous hyaluronic acid levels, as well as optimizes the effect of hydrolift® action with stabilized hybrid complexes (bioremodeling).

HYDRO

LONG TERM EFFECT:
PROFHILO®
has proven resistance to hyaluronidase (BTH), eight times higher than high molecular weight natural hyaluronic acid (> 1000kDa), without the use of stabilized linkers.

Profhilo

Low inflammatory response
Compared to natural H-HA and L-HA, PROFHILO® has a much lower activation of TGF-β, which reduces the possibility of inflammation.

Profhilo

IN VITRO AND CLINICAL RESEARCH

In vitro analysis of the effects on wound healing of high and low molecular weight chains of hyaluronan and their hybrid H-HA/L- HA complexes. D’Agostino A. et al. BMC Cell Biol 2015;16:19.
Hyaluronan hybrid cooperative complexes as a novel frontier for cellular bioprocesses reactivation. Stellavato A. et al. PLoS One 2016;11(10):e0163510.
Hybrid Complexes of High and Low Molecular Weight Hyaluronans Highly Enhance HASCs Differentiation: Implication for Facial Bioremodeling. Stellavato A. et al. Cell Physial Biochem 2017;
Efficacy, safety, and tolerance of a new injection technique for high and low molecular weight hyaluronic acid hybrid complexes. Laurino C. et al. Eplasty 2015;
Facial bioremodeling by intradermal injection of a stabilized hybrid complex of high and low molecular weight hyaluronic acid: prospective study on 30 patients. Rodriguez Abascal M. et al. Eur Aesth Plast Surg J 2015;
Hyaluronic acid hybrid cooperative complexes and the BAP (Bio Aesthetic Points) technique: the new edge in biorejuvenation. Beatini A. et al. Aesthetic Medicine 2016;2(2)

ANTIOXIDANT CREAM - PROFHILO HAENKENIUM®


MULTI-TASKING CREAM PROVIDES IMMEDIATE SKIN HYDRATION, NATURAL ANTIOXIDANTPROTECTION AND LONG-TERM ACCUMULATIVE SKIN REJUVENATION RESULTS. RESTORES FACE, NECK AND DECOLLETE SKIN FIRMNESS ELASTICITY AND TONE.


Profhilo Haenkenium® cream, is a topical formulation that provides immediate skin hydration, natural antioxidant protection and long-term accumulative skin rejuvenation results. Combining a patented Hyaluronic Acid (HA) complex with Salvia Haenkei extract, this multi-tasking complex protects, restores and improves skin cell health within one skincare product.

  • HYALURONIC ACID (HA) COMPLEX This exclusive complex combines both high molecular weight HA, which has a protective effect, restoring and maintaining the skin’s hydrolipidic film, with low molecular weight HA, which contributes to optimal hydration.
  • HAENKENIUM This patented Salvia haenkei extract enriches the formula and slows down the degradation process of HA caused by ROS, prolonging the benefits to the skin. It provides skin protection from free radical damage and improves the skin cell health.
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